Agarwal, Jyoti published the artcileWater-mediated, highly-efficient and improved protocol for the synthesis of vesamicol, its analogues and β-blockers through the highly-chemoselective aminolysis of epoxides, COA of Formula: C18H23NO2, the main research area is vesamicol analog green preparation diastereoselective; epoxide aryl piperidine chemoselective aminolysis water mediated.
An efficient, eco-friendly and cost-effective protocol was developed for the synthesis of vesamicol e.g., I, benzovesamicol, spirovesamicol, their analogs and drug mols. such as Naftopidil and SR 59230 A. In this reaction, water had played dual role i.e. of bifunctional catalyst and reaction medium, also no other chem. reagent/promotor was required to afford the products. Reaction follows 100% atom economy and was found to be highly chemo-selective. All studied reactions worked well to yield the corresponding products in excellent to near quant. yields without following the tedious and time consuming column chromatog. as purification step. Thus, this protocol provided the vesamicol and other products without generating any chem. waste to the environment.
ChemistrySelect published new progress about Aminolysis. 137419-24-0 belongs to class piperidines, name is tert-Butyl spiro[indene-1,4′-piperidine]-1′-carboxylate, and the molecular formula is C18H23NO2, COA of Formula: C18H23NO2.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem