Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile was written by Agai-Csongor, Eva;Nogradi, Katalin;Galambos, Janos;Vago, Istvan;Bielik, Attila;Magdo, Ildiko;Ignacz-Szendrei, Gyoergyi;Keseru, Gyoergy Miklos;Greiner, Istvan;Laszlovszky, Istvan;Kiss, Bela;Schmidt, Eva;Laszy, Judit;Saghy, Katalin;Gyertyan, Istvan;Zajer-Balazs, Maria;Gemesi, Larisza;Domany, Gyoergy. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Product Details of 337912-66-0 This article mentions the following:
A library of N-(heterocyclylethylcyclohexyl)arylsulfonamides such as I is prepared by automated solid-phase synthesis, with related compounds prepared by solution-phase synthesis (no data); the compounds are evaluated for their binding to the dopamine D2 and D3 receptors. I binds to the human dopamine D2 and D3 receptors with Ki values of 24 nM and 400 pM, resp.; its antipsychotic activity and cognition-enhancing activity are determined The quant. structure-activity relationship for the binding of a set of sulfonamides to dopamine D3 receptors is determined, with seven compounds evaluated on its basis for binding to dopamine D3 receptors. In the experiment, the researchers used many compounds, for example, 4-(3-(Trifluoromethyl)phenoxy)piperidine (cas: 337912-66-0Product Details of 337912-66-0).
4-(3-(Trifluoromethyl)phenoxy)piperidine (cas: 337912-66-0) belongs to piperidine derivatives. Piperidine has a role as a reagent, a protic solvent, a base, a catalyst, a plant metabolite, a human metabolite and a non-polar solvent. Several piperidine alkaloids isolated from natural herbs, were found to exhibit antiproliferation and antimetastatic effects on various types of cancers both in vitro and in vivo for example Piperine, Evodiamine, Matrine, Berberine and Tetrandine.Product Details of 337912-66-0
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem