《Convenient, benign and scalable synthesis of 2- and 4-substituted benzylpiperidines》 was written by Agai, Bela; Proszenyak, Agnes; Tarkanyi, Gabor; Vida, Laszlo; Faigl, Ferenc. Electric Literature of C13H20ClNO And the article was included in European Journal of Organic Chemistry on August 27 ,2004. The article conveys some information:
A short, scalable and environmentally benign synthesis of 2- and 4-substituted benzylpiperidines, e.g. I, has been developed. The method is based on the temperature-programmed consecutive deoxygenation and heteroaromatic ring saturation of aryl(pyridin-2-yl)- and aryl(pyridin-4-yl)methanols and aryl(pyridin-4-yl)methanones in the presence of Pd/C catalyst. The crucial roles of the temperature, the acidity and the substrate structure in the change of selectivity have been demonstrated by isolation of several substituted aryl(piperidine)methanols. The carbinols and ketones were prepared from com. available pyridinecarbaldehydes or 4-cyanopyridine and substituted bromobenzenes via organometallic intermediates. The results came from multiple reactions, including the reaction of 4-(3-Methoxybenzyl)piperidine hydrochloride(cas: 149986-58-3Electric Literature of C13H20ClNO)
4-(3-Methoxybenzyl)piperidine hydrochloride(cas: 149986-58-3) belongs to piperidines. Piperidine derivatives are also used in solid-phase peptide synthesis (SPPS) and many degradation reactions. Electric Literature of C13H20ClNO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem