On February 3, 2011, Ackermann, Jean; Conte, Aurelia; Hunziker, Daniel; Neidhart, Werner; Nettekoven, Matthias; Wertheimer, Stanley published a patent.HPLC of Formula: 1262988-77-1 The title of the patent was Piperidine-4-carboxamide derivatives as hormone sensitive lipase (HSL) inhibitors and their preparation and use for the treatment of diseases. And the patent contained the following:
The invention relates to piperidine-4-carboxamide derivatives of formula I, which are hormone sensitive lipase (HSL) inhibitors and which are useful in the treatment of diseases. Compounds of formula I wherein R1 is alkyl, cycloalkyl, haloalkyl, etc.; R2 is H, alkyl and cycloalkyl; R3 is (un)substituted indanyl, (un)substituted pyridinyl, (un)substituted pyrimidyl, etc.; R4 is H, alkyl and cycloalkyl; A1 is carbonyl, SO2, NHCO, etc.; A2 is O and NH and derivatives; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their HSL inhibitory activity. From the assay, it was determined that compound II exhibited an IC50 value of 0.04 μM. The experimental process involved the reaction of 1-Benzyl-4-hydroxypiperidine-4-carboxylic acid hydrochloride(cas: 1262988-77-1).HPLC of Formula: 1262988-77-1
The Article related to piperidinecarboxamide preparation hormone sensitive lipase hsl inhibitor treatment disease, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 1262988-77-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem