Reduction of 1-substituted pyridinium salts was written by Acheson, R. Morrin;Paglietti, Giuseppe. And the article was included in Journal of the Chemical Society in 1976.Application In Synthesis of 1-Phenylpiperidine-3-carboxamide The following contents are mentioned in the article:
Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Reduction of the pyridinium salts I (R = Ph, R1 = CONH2, R2 = H, X = Cl; R = Me, R1 = CN, R2 = H, X = I; R = Me, R1 = CONH2, R2 = H, X = MeSO4; R = PhCH2, R1 = H, R2 = Me, X = Br) with NaBH4 or Na2(S2O4) gave mixtures of mainly 1,2- and 1,4-dihydropyridines, which were analyzed by NMR. Pd-C-catalyzed hydrogenation of the dihydro derivatives gave isomerized products in some cases. This study involved multiple reactions and reactants, such as 1-Phenylpiperidine-3-carboxamide (cas: 58971-08-7Application In Synthesis of 1-Phenylpiperidine-3-carboxamide).
1-Phenylpiperidine-3-carboxamide (cas: 58971-08-7) belongs to piperidine derivatives. The piperidine ring can be found not only in more than half of the currently known structures of alkaloids, but also in many natural or synthetic compounds with interesting biological activities. Piperidine prefers a chair conformation, similar to cyclohexane. Unlike cyclohexane, piperidine has two distinguishable chair conformations: one with the N–H bond in an axial position, and the other in an equatorial position.Application In Synthesis of 1-Phenylpiperidine-3-carboxamide
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem