A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, COA of Formula: C12H18N2, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 168466-85-1, Name is (S)-1-Benzylpiperidin-3-amine, molecular formula is C12H18N2. In a Article, authors is Nakajima, Yutaka，once mentioned of 168466-85-1
Janus kinases (JAKs) regulate various inflammatory and immune responses and are targets for the treatment of inflammatory and immune diseases. As a novel class of immunomodulators targeting JAK3, 1H-pyrrolo[2,3-b]pyridine-5-carboxamide derivatives are promising candidates for treating such diseases. In chemical modification of lead compound 2, the substitution of a cycloalkyl ring for an N-cyanopyridylpiperidine in C4-position was effective for increasing JAK3 inhibitory activity. In addition, modulation of physical properties such as molecular lipophilicity and basicity was important for reducing human ether-a-go-go-related gene (hERG) inhibitory activity. Our optimization study gave compound 31, which exhibited potent JAK3 inhibitory activity as well as weak hERG inhibitory activity. In cellular assay, 31 exhibited potent immunomodulating effect on IL-2-stimulated T cell proliferation. In a pharmacokinetic study, good metabolic stability and oral bioavailability of 31 were achieved in rats, dogs, and monkeys. Further, 31 prolonged graft survival in an in vivo rat heterotopic cardiac transplant model.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 168466-85-1, help many people in the next few years.COA of Formula: C12H18N2
Reference：
Piperidine – Wikipedia,
Piperidine | C5H12581N – PubChem