Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 4395-98-6, Name is 4-Cyanopiperidine, molecular formula is , belongs to piperidines compound. In a document, author is Hosseinzadeh, Rahman, Formula: C6H10N2.
Synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles Through a One-Pot Three Component Reaction of Boronic Acids, Sodium Azide and Active Methylene Compounds Under Ball-Milling Conditions
In this study, we report a mild and efficient one-pot synthesis of 1,4,5-trisubstituted 1,2,3-triazoles via a three-component reaction of aryl boronic acids with sodium azide and active methylene compounds under ball-milling condition. In order to determine optimized reaction conditions, several grinding auxiliaries (basic, neutral and acidic alumina, silica gel, K10 and KSF), bases (DBU, DABCO, piperidine, triethylamine, potassium t-butoxide and potassium carbonate) and copper salts under ball-milling conditions were examined. Using the optimized condition procedure, a wide variety of 1,4,5-trisubstituted 1,2,3-triazole derivatives were prepared in very good yields. All products were well-characterized by H-1-NMR and C-13-NMR spectroscopy. This environmentally friendly protocol offers several advantages including high yields of products, relatively short reaction time and simple work-up procedure.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 4395-98-6, in my other articles. Formula: C6H10N2.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem