Chemistry can be defined as the study of matter and the changes it undergoes. You¡¯ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 41979-39-9, Name is Piperidin-4-one hydrochloride, molecular formula is , belongs to piperidines compound. In a document, author is Souissi, Salma, Recommanded Product: Piperidin-4-one hydrochloride.
Kinetics and quantification of the electrophilic reactivities of substituted thiophenes and structure-reactivity relationships
Second-order rate constants (k(1)) have been measured spectrophotometrically for reactions of 2-methoxy-3-X-5-nitrothiophene 1a-c (X = NO2, CN, and COCH3) with secondary cyclic amines (pyrrolidine 2a, piperidine 2b, and morpholine 2c) in CH3CN and 91:9 (v/v) CH3OH/CH3CN at 20 degrees C. The experimental data show that the rate constants (k(1)) values exhibit good correlation with the parameters of nucphilicity (N) of the amines 2a-c and are consistent with the Mayr’s relationship log k (20 degrees C) = s(E + N). We have shown that the electrophilicity parameters E derived for 1a-c and those reported previously for the thiophenes 1d-g (X=SO2CH3, CO2CH3, CONH2, and H) are linearly related to the pK(a) values for their gem-dimethoxy complexes in methanol. Using this correlation, we successfully evaluated the electrophilicity E values of 12 structurally diverse electrophiles in methanol for the first time. In addition, a satisfactory linear correlation (r(2) = 0.9726) between the experimental (log k(exp)) and the calculated (log k(calcd)) values for the sigma-complexation reactions of these 12 electrophiles with methoxide ion in methanol has been observed and discussed.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 41979-39-9, in my other articles. Recommanded Product: Piperidin-4-one hydrochloride.
Reference:
Piperidine – Wikipedia,
,Piperidine | C5H11N – PubChem