Reference of 68947-43-3, Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 68947-43-3, Name is 1-Methylpiperidine-4-carboxylic acid, molecular formula is C7H13NO2. In a Article，once mentioned of 68947-43-3
A new series of 4-aminopyridyl-based lead inhibitors targeting Trypanosoma cruzi CYP51 (TcCYP51) has been developed using structure-based drug design as well as structure-property relationship (SPR) analyses. The screening hit starting point, LP10 (KD ? 42 nM; EC50 = 0.65 muM), has been optimized to give the potential leads 14t, 27i, 27q, 27r, and 27t, which have low-nanomolar binding affinity to TcCYP51 and significant activity against T. cruzi amastigotes cultured in human myoblasts (EC50 = 14-18 nM for 27i and 27r). Many of the optimized compounds have improved microsome stability, and most are selective against human CYPs 1A2, 2D6, and 3A4 (<50% inhibition at 1 muM). A rationale for the improvement in microsome stability and selectivity of inhibitors against human metabolic CYP enzymes is presented. In addition, the binding mode of 14t with the Trypanosoma brucei CYP51 (TbCYP51) orthologue has been characterized by X-ray structure analysis. Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Reference of 68947-43-3, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 68947-43-3, in my other articles.
Reference：
Piperidine – Wikipedia,
Piperidine | C5H6988N – PubChem