Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels.In a patent， Recommanded Product: 165528-81-4, Which mentioned a new discovery about 165528-81-4
Matriptase belongs to trypsin-like serine proteases involved in matrix remodeling/degradation, growth regulation, survival, motility, and cell morphogenesis. Herein, we report a structure-based approach, which led to the discovery of sulfonamide and amide derivatives of pyridyl bis(oxy)benzamidine as potent and selective matriptase inhibitors. Co-crystal structures of selected compounds in complex with matriptase supported compound designing. Additionally, WaterMap analyses indicated the possibility of occupying a distinct pocket within the catalytic domain, exploration of which resulted in >100-fold improvement in potency. Co-crystal structure of 10 with matriptase revealed critical interactions leading to potent target inhibition and selectivity against other serine proteases.
Because enzymes can increase reaction rates by enormous factors and tend to be very specific, Recommanded Product: 165528-81-4, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 165528-81-4
Reference：
Piperidine – Wikipedia,
Piperidine | C5H18433N – PubChem