The author of 《Hydroxyl-substituted double Schiff-base condensed 4-piperidone/cyclohexanones as potential anticancer agents with biological evaluation》 were Zhang, Lianshuang; Chen, Qin; Hou, Guige; Zhao, Wei; Hou, Yun. And the article was published in Journal of Enzyme Inhibition and Medicinal Chemistry in 2019. Computed Properties of C6H11NO The author mentioned the following in the article:
Novel hydroxyl-substituted double Schiff-base 4-piperidone/cyclohexanone derivatives, and , were synthesized and fully characterized by 1H NMR, IR and elemental anal. The cytotoxicity against human carcinoma cell lines A549, SGC7901, HePG2, HeLa, K562, THP-1 and non-malignant LO2 cell lines were evaluated. The results showed 4-piperidinone derivatives displayed better cytotoxicity than cyclohexanone derivatives, especially for 3,4,5-trihydroxyphenyl-substituted BAP . The western blot and flow cytometry results proved can effectively promote cell apoptosis through up-regulating Bax protein and down-regulating Bcl-2 protein expression. Mol. docking modes showed that could reasonably bind to the active site of Bcl-2 protein through strong intermol. hydrogen bonds and significant hydrophobic effect. In vivo, can effectively suppress the growth of HepG2 xenografts without apparent body weight changes. This study indicates that can be a potential anticancer agent for early treatment of liver cancers. The experimental process involved the reaction of 1-Methyl-4-piperidone(cas: 1445-73-4Computed Properties of C6H11NO)
1-Methyl-4-piperidone(cas: 1445-73-4) is a member of piperidine. Piperidine is a key saturated heterocyclic scaffold found in several of the top-selling small molecule pharmaceuticals and natural alkaloids, with a diverse range of biological activities. Hence, continuous efforts have been made to develop convenient methods to prepare piperidine derivatives.Computed Properties of C6H11NO
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem