Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Synthetic Route of 5382-16-1.
Wang, Jing;Liu, Hang;Zhuo, Xiao-Bin;Ye, Guang-Ming;Zhao, Qing-Jie research published 《 Synthesis and Biological Evaluation of the Matrine Derivatives as a Novel Family of Potential Anticancer Agents》, the research content is summarized as follows. FufangKushen injection′ was a Chinese Traditional anticancer drug, which has been widely used to treat cancer in combination with other anticancer drugs. Our goal is to synthesize a series of novel 13-dithiocarbamates matrine derivatives using matrine (1) as the lead compound, and evaluate the biol. activities of the obtained compounds The in vitro cytotoxicity of the target compounds against three human cancer cell lines (Hep3B, LM3 and BeL-7404) was evaluated. To investigate the mechanism of biol. activity, cell cycle anal. was performed. The results revealed that compounds 6o and 6v displayed the most significant anticancer activity against three cancer cell lines with IC50 values in the range of 3.42-8.05 μM, which showed better activity than the parent compound (Matrine). SAR anal. indicated that the introduction of a substituted amino dithiocarbamate might significantly enhance the antiproliferative activity. During the newly synthesized compounds, matrine analog 6v exhibited a potent effect against three human tumor cell lines. The mode of action of 6v was to inhibit the G0/G1 phase arrest. Therefore, compound 6v has been selected as a novel-scaffold lead to further structural optimizations or as a chem. probe for exploring anticancer pathways of this kind of compounds
5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Synthetic Route of 5382-16-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem