Piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. This gave the compound its name. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Other examples are the fire ant toxin solenopsin, the nicotine analog anabasine of tree tobacco (Nicotiana glauca), lobeline of Indian tobacco. Electric Literature of 5382-16-1.
Wang, Chenyang;Azofra, Luis Miguel;Dam, Phong;Sebek, Michael;Steinfeldt, Norbert;Rabeah, Jabor;El-Sepelgy, Osama research published 《 Catalytic Desaturation of Aliphatic Amides and Imides Enabled by Excited-State Base-Metal Catalysis》, the research content is summarized as follows. A photoexcited base-metal-catalyzed selective desaturation of aliphatic amides and imides was reported. The reaction was catalyzed by a base-metal cobalt complex under visible-light irradiation This transformation could be efficiently processed at room temperature and enabled the synthesis of valuable cyclic and acyclic enamides and enimides from abundant chems. D. functional theory (DFT) anal., ESR (EPR) and UV-vis studies rationalized the discovered reactivity of the cobalt catalyst for the photochem. C(sp3)-H activation reaction. Finally, demonstrated the potential of process by scaling-up experiments using a continuous flow photoreactor.
Electric Literature of 5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem