With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.287952-67-4,4-(4-Trifluoromethoxyphenoxy)piperidine,as a common compound, the synthetic route is as follows.
General procedure: Example 1(S)-N-(6,7-dihydro-2-nitro-5H-imidazo[2,1-b][1,3]oxazin-6-yl)-2-(4-(4-(trifluoromethoxy)phenoxy) piperidin-1-yl) acetamide (1) [0098] Under argon protection, (S)-2-chloro-N-(2-nitro-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazin-6-yl) acetamide (130 mg, 0.50 mmol) was dissolved in anhydrous DMF (2 ml), added 4-(4-trifluoromethoxy)phenoxy) piperidine (261 mg, 1.0 mmol), potassium carbonate (207mg, 1.5 mmol), sitrred overnight at 50 C, separated by column chromatography to give title compound as 102 mg yellow powder, yield was 42 %.1H NMR (400 MHz, CDCl3): delta 2.42-2.53 (m, 8H), 3.44 (m, 2H), 3.47 (s, 2H), 4.19-4.28 (m, 3H), 4.47-4.52 (m, 2H), 4.62-4.63 (m, 1H), 7.15 (d, J = 8.0 Hz, 2H), 7.32 (d, J = 8.0 Hz, 2H), 7.41 (s, 1H), 7.92 (d, J = 7.2 Hz, 1H). ESI-LR: 486.3 [M+1]+.
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Reference£º
Patent; Shanghai Sun-Sail Pharmaceutical Science & Technology Co., Ltd; WANG, Tiancai; XIN, Ting; FAN, Houxing; CHEN, Yilang; EP2573090; (2013); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem