Industrially, piperidine is produced by the hydrogenation of pyridine, usually over a molybdenum disulfide catalyst: C5H5N + 3 H2 → C5H10NH. 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Pyridine can also be reduced to piperidine via a modified Birch reduction using sodium in ethanol. Reference of 5382-16-1.
Ishchenko, Roman A.;Kargapolova, Irina Yu.;Orlova, Natalia A.;Shelkovnikov, Vladimir V.;Maksimov, Alexander M.;Ryazanov, Nikita D.;Berezhnaya, Viktoria N.;Chernonosov, Alexander A. research published 《 Polyfluorinated triphenyl-4,5-dihydro-1H-pyrazoles with dendroid arylsulfanyl moieties as donor blocks in donor-acceptor chromophores》, the research content is summarized as follows. A series of novel donor-acceptor chromophores were synthesized using formylated derivatives of polyfluorinated triarylpyrazolines with branched moieties as donor blocks and dicyanoisophorone as acceptor. The nucleophilic substitution of fluorine with 4-hydroxypiperidine in decafluoropyrazoline was used to further functionalize the chromophore mol. An existing method for introducing the dendroid moiety was improved. The properties of the final chromophores were estimated by DFT calculations
5382-16-1, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., Reference of 5382-16-1
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem