Piperidine was first reported in 1850 by the Scottish chemist Thomas Anderson and again, independently, in 1852 by the French chemist 5382-16-1, formula is C5H11NO, Name is 4-Piperidinol. Auguste Cahours, who named it. Both of them obtained piperidine by reacting piperine with nitric acid. Category: piperidines.
Di Porzio, Anna;Galli, Ubaldina;Amato, Jussara;Zizza, Pasquale;Iachettini, Sara;Iaccarino, Nunzia;Marzano, Simona;Santoro, Federica;Brancaccio, Diego;Carotenuto, Alfonso;De Tito, Stefano;Biroccio, Annamaria;Pagano, Bruno;Tron, Gian Cesare;Randazzo, Antonio research published 《 Synthesis and Characterization of Bis-Triazolyl-Pyridine Derivatives as Noncanonical DNA-Interacting Compounds》, the research content is summarized as follows. Besides the well-known double-helical conformation, DNA is capable of folding into various noncanonical arrangements, such as G-quadruplexes (G4s) and i-motifs (iMs), whose occurrence in gene promoters, replication origins, and telomeres highlights the breadth of biol. processes that they might regulate. Particularly, previous studies have reported that G4 and iM structures may play different roles in controlling gene transcription. Anyway, mol. tools able to simultaneously stabilize/destabilize those structures are still needed to shed light on what happens at the biol. level. Herein, a multicomponent reaction and a click chem. functionalization were combined to generate a set of 31 bis-triazolyl-pyridine derivatives which were initially screened by CD for their ability to interact with different G4 and/or iM DNAs and to affect the thermal stability of these structures. All the compounds were then clustered through multivariate data anal., based on such capability. The most promising compounds were subjected to a further biophys. and biol. characterization, leading to the identification of two mols. simultaneously able to stabilize G4s and destabilize iMs, both in vitro and in living cells.
Category: piperidines, 4-Hydroxypiperidine is a molecule with a carbonyl group. It is the most active and selective CCR5 receptor antagonist that has been studied to date. 4-Hydroxypiperidine inhibits HIV infection by preventing the binding of HIV to its receptor on the surface of white blood cells, thereby preventing it from entering these cells. 4-Hydroxypiperidine also acts as an anti-inflammatory agent in chronic bronchitis patients, due to its ability to inhibit prostaglandin synthesis. The chemical ionization mass spectra of this molecule show peaks for methyl ethyl, malic acid, and hydroxyl groups. These properties make 4-hydroxypiperidine a useful candidate for drug development against inflammatory diseases and several cancers.
The molecular structure, vibrational spectra, NBO and UV-spectral analysis of 4-Hydroxypiperidine have been studied. The compounds with a substituted 4-piperidinol core have been found to be potent antagonists of the human H receptor., 5382-16-1.
Referemce:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem