A new synthetic route of 23794-15-2

This compound(1-(2-chloropyridine-4-yl)ethanone)Quality Control of 1-(2-chloropyridine-4-yl)ethanone was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Bellale, Eknath; Naik, Maruti; Varun, V. B.; Ambady, Anisha; Narayan, Ashwini; Ravishankar, Sudha; Ramachandran, Vasanthi; Kaur, Parvinder; McLaughlin, Robert; Whiteaker, James; Morayya, Sapna; Guptha, Supreeth; Sharma, Sreevalli; Raichurkar, Anandkumar; Awasthy, Disha; Achar, Vijayshree; Vachaspati, Prakash; Bandodkar, Balachandra; Panda, Manoranjan; Chatterji, Monalisa published an article about the compound: 1-(2-chloropyridine-4-yl)ethanone( cas:23794-15-2,SMILESS:CC(=O)C1=CC(Cl)=NC=C1 ).Quality Control of 1-(2-chloropyridine-4-yl)ethanone. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:23794-15-2) through the article.

Diarylthiazole (DAT), a hit from diversity screening, was found to have potent antimycobacterial activity against Mycobacterium tuberculosis (Mtb). In a systematic medicinal chem. exploration, the authors demonstrated chem. opportunities to optimize the potency and physicochem. properties. The effort led to more than 10 compounds with submicromolar MICs and desirable physicochem. properties. The potent antimycobacterial activity, in conjunction with low mol. weight, made the series an attractive lead (antibacterial ligand efficiency (ALE) >0.4). The series exhibited excellent bactericidal activity and was active against drug-sensitive and resistant Mtb. Mutational anal. showed that mutations in prrB impart resistance to DAT compounds but not to reference drugs tested. The sensor kinase PrrB belongs to the PrrBA two component system and is potentially the target for DAT. PrrBA is a conserved, essential regulatory mechanism in Mtb and has been shown to have a role in virulence and metabolic adaptation to stress. Hence, DATs provide an opportunity to understand a completely new target system for antimycobacterial drug discovery.

This compound(1-(2-chloropyridine-4-yl)ethanone)Quality Control of 1-(2-chloropyridine-4-yl)ethanone was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.

Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem