In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Identification of pyrimidine derivatives as hSMG-1 inhibitors, published in 2012-11-01, which mentions a compound: 23794-15-2, mainly applied to pyrimidine derivative preparation structure SMG1 kinase inhibitor cancer, SDS of cas: 23794-15-2.
HSMG-1 kinase plays a dual role in a highly conserved RNA surveillance pathway termed nonsense-mediated RNA decay (NMD) and in cellular genotoxic stress response. Since deregulation of cellular responses to stress contributes to tumor growth and resistance to chemotherapy, hSMG-1 is a potential target for cancer treatment. From our screening efforts, we have identified pyrimidine derivatives as hSMG-1 kinase inhibitors. We report structure-based optimization of this pan-kinase scaffold to improve its biochem. profile and overall kinome selectivity, including mTOR and CDK, to generate the first reported selective hSMG-1 tool compound
Different reactions of this compound(1-(2-chloropyridine-4-yl)ethanone)SDS of cas: 23794-15-2 require different conditions, so the reaction conditions are very important.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem