Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 175136-62-6, is researched, SMILESS is FC(C1=CC(C(F)(F)F)=CC(P(C2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)C3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=C1)(F)F, Molecular C24H9F18PJournal, Article, Research Support, Non-U.S. Gov’t, Inorganic Chemistry called Anticancer C,N-Cycloplatinated(II) Complexes Containing Fluorinated Phosphine Ligands: Synthesis, Structural Characterization, and Biological Activity, Author is Cutillas, Natalia; Martinez, Alexandra; Yellol, Gorakh S.; Rodriguez, Venancio; Zamora, Ana; Pedreno, Monica; Donaire, Antonio; Janiak, Christoph; Ruiz, Jose, the main research direction is platinum cyclometalated dimethylbenzylamine fluorophosphine complex preparation anticancer biol activity; fluorophosphine platinum antitumor human breast ovary cathepsin B inhibitor; crystal structure mol platinum cyclometalated dimethylbenzylamine fluorinated phosphine complex.Synthetic Route of C24H9F18P.
A series of potent C,N-cycloplatinated-(II) phosphine antitumor complexes containing fluorous substituents in the cyclometalated or the ancillary phosphine ligands [Pt-(C-N)-(PR3)-Cl] or both have been synthesized and characterized. The crystal structure of [Pt-(dmba)-{P-(C6H4CF3-p)3}-Cl]·2CH2Cl2 (dmba = dimethylaminomethyl-phenyl) has been established by X-ray diffraction. Values of IC50 of the new platinum complexes were calculated toward a panel of human tumor cell lines representative of ovarian (A2780 and A2780cisR) and breast cancers (T47D). Complexes containing P-(C6H4CF3-p)3 as ancillary ligand (with a bulky and electroneg. CF3 substituent in para position) were the most cytotoxic compounds in all the tested cancer cell lines. In some cases, the IC50 values were 16-fold smaller than that of cisplatin and 11-fold smaller than the non-fluorous analog [Pt-(dmba)-(PPh3)-Cl]. On the other hand, very low resistance factors (RF) in A2780cisR (cisplatin-resistant ovarian carcinoma) at 48 h were observed (RF ≈ 1) for most of the new compounds Anal. of cell cycle was done for the three more active compounds in A2780. They arrest cell growth in G0/G1 phase in contrast to cisplatin (S phase) with a high incidence of late-stage apoptosis. They are also good cathepsin B inhibitors (an enzyme implicated in a number of cancer related events).
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Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem