In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Aminations and arylations by direct C-O activation for the design of 7,8-dihydro-6H-5,8-ethanopyrido[3,2-d]pyrimidines, published in 2021, which mentions a compound: 144230-52-4, mainly applied to arylboronic acid dihydroethanopyridopyrimidinone palladium RuPhos catalyst Suzuki cross coupling; amine dihydroethanopyridopyrimidinone palladium xantphos catalyst Buchwald Hartwig cross coupling; dihydroethanopyridopyrimidinone amine PyBroP activator nucleophilic aromatic substitution; dihydroethanopyridopyrimidinamine preparation, Related Products of 144230-52-4.
The design of some novel disubstituted 7,8-dihydro-6H-5,8-ethanopyrido[3,2-d]pyrimidine derivatives was reported. The series was developed from quinuclidinone, which afforded versatile platforms bearing one lactam function in position C-2 that were then used to create C-N or C-C bonds for SNAr or palladium-catalyzed cross-coupling reactions by in situ C-O activation. The reaction conditions were optimized under microwave irradiation and a wide range of amines or boronic acids were used to determine the scope and limitations of each method. To complete this study, the X-ray crystallog. data of 4-Phenyl-2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-6H-5,8-ethanopyrido[3,2-d]pyrimidine were used to formally establish the structures of the products.
Compound(144230-52-4)Related Products of 144230-52-4 received a lot of attention, and I have introduced some compounds in other articles, similar to this compound(4,4-Difluoropiperidine hydrochloride), if you are interested, you can check out my other related articles.
Reference:
Piperidine – Wikipedia,
Piperidine | C5H11N – PubChem