236406-39-6, 8-Boc-2,8-Diazaspiro[4.5]decane is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 50 tert-butyl 2-[4-(2-{[tert-butyl(dimethyl)silyl]oxy}ethyl)phenyl]-2,8-diazaspiro[4.5]decane-8-carboxylate Under an argon atmosphere, an anhydrous toluene (1 mL) solution of trisdibenzylideneacetone dipalladium (21 mg), biphenyl-2-yl(dicyclohexyl)phosphine (32 mg) and tert-butoxy potassium (306 mg) was stirred at room temperature for one hour. To this solution, an anhydrous toluene (2 mL) solution of the compound (714 mg) obtained in Example 49 and tert-butyl 2,8-diazaspiro[4.5]decane-8-carboxylate (594 mg) was added. The reaction solution was stirred at 100C for one hour. The reaction solution was cooled to room temperature, and then water (10 mL) was added. The aqueous layer was filtered through Celite (trade name). The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with saturated brine and then dried over anhydrous magnesium sulfate. After removing the anhydrous magnesium sulfate by filtration, the filtrate was concentrated under reduced pressure. The residue was purified by silica gel chromatography (n-hexane:ethyl acetate=98:2?77:23) to obtain the title compound (683 mg) having the following physical properties. TLC: Rf 0.24(n-hexane:ethyl acetate=19:1); NMR(CDCl3):delta 7.07 (d, J=8.4Hz, 2H), 6.48 (d, J=8.4Hz, 2H), 3.73 (t, J=6.9Hz, 2H), 3.49 (m, 2H), 3.36 (m, 4H), 3.14 (s, 2H), 2.73 (t, J=6.9Hz, 2H), 1.87 (t, J=6.9Hz, 2H), 1.56 (m, 4H), 1.46 (s, 9H), 0.89 (s, 9H), -0.03 (s, 6H).
As the paragraph descriping shows that 236406-39-6 is playing an increasingly important role.
Reference£º
Patent; ONO PHARMACEUTICAL CO., LTD.; EP1961744; (2008); A1;,
Piperidine – Wikipedia
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