929252-65-3,929252-65-3, tert-Butyl 4-(((4-(4-amino-2-fluorophenoxy)-6-methoxyquinolin-7-yl)oxy)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Step I: Preparation of tert-butyl [0106] 4-[[4-[2-fluoro-4-[[1-[(4-fluorophenyl)aminocarbonyl]cyclopropanecarbonyl]amino]phenoxy]-6-method xy-7-quinolyl]oxymethyl]piperidine-1-carboxylate: A mixture of Intermediate C (1.5 g, 3.0 mmol), Intermediate D (1.7 g, 7.6 mmol), DIPEA (1.55 g, 12.0 mmol), HATU (2.3 g, 6.0 mmol), DMAP (0.183 g, 1.5 mmol) in 60 mL of DMF was stirred at 30-40 C overnight, then concentrated under reduced pressure. The residue was purified by column chromatography (eluted with 1-5% MeOH in DCM) to afford the target product (1.9 g, yield: 90%). The characterization of the resulting product was as follows: Mass spectrum m/z: 703.30 [M+H].
As the paragraph descriping shows that 929252-65-3 is playing an increasingly important role.
Reference：
Patent; Beijing Konruns Pharmaceutical Co., Ltd.; Guangzhou ESA Biotech Co., Ltd.; YUN, Ziwei; WANG, Hongtao; EP2769976; (2014); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem