With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.873779-30-7,tert-Butyl 5-bromo-2-oxospiro[indoline-3,4′-piperidine]-1′-carboxylate,as a common compound, the synthetic route is as follows.
To R8, purchased from ACTIVATE (200 mg, 0.53 mmol) in DMF (4 mL) is added sodium hydride (60% dispersion in mineral oil, 31.5 mg, 0.79 mmol) under cooling to 0 C. and reaction mixture is stirred for further 30 minutes at r.t. Methyl iodide (36 muL, 0.58 mmol) is added and the reaction mixture is stirred for 40 minutes at r.t. The reaction mixture is diluted with water and extracted with ethyl acetate. The organic layer is washed with water and brine, dried over Na2SO4, filtered and concentrated in vacuo to provide R9. Yield 98%., 873779-30-7
The synthetic route of 873779-30-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Boehringer Ingelheim International GmbH; VINTONYAK, Viktor; GRAUERT, Matthias; GRUNDL, Marc; PAUTSCH, Alexander; (64 pag.)US2016/75704; (2016); A1;,
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