With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.
10338-57-5, General procedure: o-amino thiophenol (1mmol), aromatic aldehyde (1.1mmol) andwater (10mL) were mixed in 25mL single neck round bottom flask, andto this Ammonium Nickel Sulphate (10 mol %) was added. The reactionmixture was sonicated at room temperature (250C) for the appropriate time(Table 2, entries 13-25), and the progress of reaction was monitored by TLC.After completion of reaction, the mixture was extracted with ethyl acetate(2×10mL). The combined organic layer was dried over anhydrous Na2SO4 andevaporated under reduced pressure; the crude material was purified by columnchromatography over silica gel to afford products 4a-4m with high purity.
As the paragraph descriping shows that 10338-57-5 is playing an increasingly important role.
Reference：
Article; Pardeshi, Sandeep D.; Sonar, Jayant P.; Pawar, Shivaji S.; Dekhane, Deepak; Gupta, Sunil; Zine, Ashok M.; Thore, Shivaji N.; Journal of the Chilean Chemical Society; vol. 59; 1; (2014); p. 2335 – 2340;,
Piperidine – Wikipedia
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