With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.63845-28-3,2-(1-((Benzyloxy)carbonyl)piperidin-4-yl)acetic acid,as a common compound, the synthetic route is as follows.
(4-({ [(3-Chloro-pyrazin-2-yl)-(2-phenyl-quinolin-7-yl)-methyl]-carbamoyl}-methyl)- piperidine-1-carboxylic acid benzyl ester); [1123] (3-Chloropyrazin-2-yl)(2-phenylquinolin-7-yl)-methanamine (120.00 mg, 0.35 mmol), EDC (100.64 mg, 0.53 mmol) and HOBt (47.29 mg, 0.35 mmol) were suspended in CH2C12 (2 mL) and charge with DIEA (122.00 muL, 0.70 mmol) followed by the addition of 1- N-Cbz-4-piperidineacetic acid (127.56 mg, 0.46 mmol). The reaction mixture was stirred at rt for 16 h. The reaction mixture was diluted with CH2Cl2 (10 mL) and washed with saturated NaHC03 (2 x 20 mL) and brine (2 x 20 mL). The organic layer was dried over Na2S04 and concentrated in vacuo. The crude product was purified by a 10 g Jones silica gel (wetted with 50% EtOAc/ Hexane, dried loaded onto silica, and run with 60% EtOAc/ Hexanes – 70% EtOAc/ Hexanes) affording the desired product; ?H NMR (400 MHz, CHLOROFORM-d) 8 8.56 (1 H, d, J=2.47), 8.39 (1 H, d, J= 2.50), 8.23 (1 H, d, J= 4.77), 8.11 (2 H, d, J= 7.06), 7.85 (3 H, dd, J= 8.60, J= 8.38), 7.74 (1 H, s), 7.50 (3H, m), 7.32 (6H, m), 6.78 (1 H, d, J= 7.76), 5.10 (2 H, s), 4.11 (2 H, m), 2.75 (2 H, m), 2.21 (2 H, d, J= 7.00), 2.01 (1 H, m), 1.67 (2 H, m), 1.15 (2 H, d, J= 8.921) ; MS (ES+): m/z 605.96/606.98/608.93 (100/40/15) [MH(at)] ; HPLC: tR = 3.33 min. (OpenLynx, nonpolar_5min.).
63845-28-3, The synthetic route of 63845-28-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; OSI PHARMACEUTICALS, INC.; WO2005/97800; (2005); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem