With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5274-99-7,1-Benzoylpiperidine-4-carboxylic acid,as a common compound, the synthetic route is as follows.
A mixed solution of methyl (2R, 3S)-2-AMINO-3- (LH-INDOL-3- yl) butanoate (1.28 g), 1-benzoylpiperidine-4-carboxylic acid (1.54 g), WSC (1.58 g) and HOBt (1.10 g) in acetonitrile (50 mL) was stirred at room temperature for 16 hrs. The reaction solution was diluted with ethyl acetate, a saturated aqueous solution of sodium carbonate was added and the mixture was subjected to extraction. The extract was purified by silica gel column chromatography (developing solvent: hexane/ethyl acetate = 1/1-1/4-ethyl acetate) to give the title compound as a pale yellow powder (2.01 g, yield 82%). LC/MS (ESI) m/z 448 (M+H+)., 5274-99-7
The synthetic route of 5274-99-7 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; TAKEDA CHEMICAL INDUSTRIES, LTD.; WO2004/46107; (2004); A1;,
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