With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.768-66-1,2,2,6,6-Tetramethylpiperidine,as a common compound, the synthetic route is as follows.
768-66-1, The A-1 (11.48g, 41.5mmol) was dissolved in 300mL of THF, cooled to 0 , the mixture was added LTMP (LTMP Synthesis: in 500mL of THF, maintained 0 dissolved 0.13molBuLi, 0.14mol 2, 2,2,6,6-tetramethyl piperidine). 0C reaction was stirred for 2 hours, the reaction was quenched with water 200mL, layer of water, the organic layer was spin-dry, with dichloromethane: petroleum ether = 10: 1 (volume ratio) through the column was isolated as a solid (B-1) ( 4.87g, y = 48%).
768-66-1 2,2,6,6-Tetramethylpiperidine 13035, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Jilin Optical and Electronic Materials Co., Ltd; Gao, Chunji; Wang, Shikai; Wang, Zhao; Qin, Cuiying; Yin, Enxin; Cui, Dunzhu; (87 pag.)CN105693631; (2016); A;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem