With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.72752-52-4,2-Piperidinobenzonitrile,as a common compound, the synthetic route is as follows.
Example 3-6; 2-(2-(1-piperidinyl)phenyl)hexanoic acid; This acid was prepared in 3 steps from 2-(1-piperidinyl)benzonitrile intermediate (see example 2-1). Step 1; 1-(2-(1-piperidinyl)phenyl)pentan-1-ol; Under anhydrous atmosphere, 2-(1-piperidinyl)benzonitrile (15 g, 80.5 mmol) was solubilized in anhydrous THF (75 ml) and freshly prepared butylmagnesium bromide (242 mmol in 100 ml THF) was added. The mixture was refluxed overnight. The crude was then hydrolyzed with water and acidified with 1M HCl until a pH close to 7 was obtained. The resulting ketone was extracted with ethyl acetate, dried with magnesium sulfate (MgSO4), and concentrated. The residue was taken in methanol (150 ml) and the solution was cooled with an ice bath. Sodium borohydride (6.1 g, 161 mmol) was added portionwise at 0 C. and the crude was warmed to room temperature. Upon total ketone consumption (according to TLC), water was added and the expected compound was extracted with ethyl acetate, dried with magnesium sulfate (MgSO4), and concentrated. The expected product was isolated by silica gel chromatography (cyclohexane/ethyl acetate 95/5). Yield: 55%, 72752-52-4
The synthetic route of 72752-52-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; GENFIT; US2006/79696; (2006); A1;,
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