With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141774-61-0,tert-Butyl (piperidin-2-ylmethyl)carbamate,as a common compound, the synthetic route is as follows.
A mixture of 2,4-dichloro-5-fluoropyrimidine (167 mg, 1.00 mmol), 2-N-Boc- aminomethyl piperidine (214 mg, 1.00 mmol) and DIEA (0.400 mL, 2.30 mmol) in CH3CN (4 mL) was stirred at room temperature for 20 h. It was concentrated in vacuo. The residue was dissolved in nBuOH (6 mL). 3 mL of the nBuOH solution was taken, to which l-(4-(4- aminophenyl)piperazin-l-yl)ethanone (142 mg, 0.65 mmol) was added. The solution was stirred at 116 0C for 20 h. nBuOH was removed in vacuo. The residue was purified by HPLC to give tert-butyl (l-(2-(4-(4-acetylpiperazin-l-yl)phenylamino)-5-fluoropyrimidin-4- yl)piperidin-2-yl)methylcarbamate (56 mg). MS 528.4 (M+H).
141774-61-0, As the paragraph descriping shows that 141774-61-0 is playing an increasingly important role.
Reference：
Patent; PORTOLA PHARMACEUTICALS, INC.; WO2009/131687; (2009); A2;,
Piperidine – Wikipedia
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