With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.221874-51-7,(R)-tert-Butyl (2-oxopiperidin-3-yl)carbamate,as a common compound, the synthetic route is as follows.
Preparation of Compound 148Step 1:(S)-tert-Butyl (l-ethyl-2-oxopiperidin-3-yl)carbamate. (S)-tert-bvAy (2-oxopiperidin- 3-yl)carbamate (1 g, 4.67 mmol) was dissolved in THF (10 mL) and the solution cooled to 0C. A 1M solution of LiHMDS (5.4 mL) in THF was added and the mixture stirred for 1 h. Iodoethane (410 iL, 5.1 mmol) was added and the reaction removed from the cooling bath and allowed to warm to room temperature and stirred overnight. The reaction was quenched with saturated aqueous NH4C1 (8 vol) and extracted with EtOAc (2 x 4 vol). The combined extracts were washed with brine, dried, filtered and evaporated. The desired product was isolated by silica gel chromatography to afford tert-butyl N- [(3S)-l-ethyl-2-oxo-3-piperidyl]carbamate. Yield: (190 mg, 16.8%). MS: m/z (obs.) 507.0 [M+H]+. IH NMR (400 MHz, CDC13) delta 6.86 (d, J = 7.8 Hz, IH), 3.85 (s, IH), 3.30 – 3.15 (m, 5H), 1.84 (ddd, J = 26.1, 16.9, 12.3 Hz, 5H), 1.38 (s, 10H), 1.01 (t, J = 7.1 Hz, 3H).
221874-51-7, As the paragraph descriping shows that 221874-51-7 is playing an increasingly important role.
Reference：
Patent; VERTEX PHARMACEUTICALS INCORPORATED; GREEN, Jeremy; WILSON, Dean, M.; KONG, Laval, Chan Chun; DAS, Sanjoy, Kumar; POISSON, Carl; COURT, John, J.; TANG, Qing; LI, Pan; COLLIER, Philip, N.; WAAL, Nathan; LAUFFER, David, J.; DORSCH, Warren; WO2012/6055; (2012); A2;,
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