With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1062580-52-2,(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride,as a common compound, the synthetic route is as follows.
A. Mix 10.0 kg of purified water, 2.6 kg of acetonitrile, 1.7 kg (3R, 4R) -1-benzyl-N, 4-dimethylpiperidine-3-amine dihydrochloride and 2.3 kg of potassium carbonate, and stir To dissolve B. Add 1.8 kg of 4-chloro-7-p-toluenesulfonyl-pyrrolo [2,3-d] pyrimidin-4-amine to the product obtained in the previous step several times, and raise the temperature to 75-85 C for 10 hours for reaction. HPLC detection; C. Reduce the temperature to 20-30 C and stir for 2 hours, suction filter, wash the filter cake with 3kg of purified water and set aside;, 1062580-52-2
1062580-52-2 (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride 45790119, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; Jiangsu Haiyuekang Pharmaceutical Technology Co., Ltd.; Pei Xinyu; Chen Zeming; Xie Rongguang; (12 pag.)CN110668995; (2020); A;,
Piperidine – Wikipedia
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