With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.62718-31-4,1-Benzylpiperidine-4-carbonitrile,as a common compound, the synthetic route is as follows.
Step a: To solution of LHMDS (1 M in THF, 16.45 mL, 16.45 mmol) was added a solution of 1-benzylpiperidine-4-carbonitrile (1.50 g, 7.49 mmol) in THF (37.4 mL) at – 78 C. The resulting yellow solution was stirred for 1 h at -78 C. 1-Iodo-2-methylpropane (5.60mL, 48.7 mmol) was added and the reaction mixture was allowed to warm up to RT and stirring was continued for 3 days. Saturated aq. NH4C1 (-30 mL) was added at 0 C and the mixture was extracted with EtOAc. The organic phase was washed with water (50 mL) and brine (50 mL). Each aq. layer was extracted with EtOAc and the combined organic phases were dried over Na2SO4, filtered, and concentrated under reduced pressure to give crude 1 -benzyl-4- isobutylpiperidine-4-carbonitrile (2.54 g) as a yellow oil, which was directly used without further purification. MS m/z 257.3 (M+H)., 62718-31-4
The synthetic route of 62718-31-4 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; NOVARTIS AG; CHEN, Zhuoliang; FORTANET, Jorge Farcia; LAMARCHE, Matthew J.; SENDZIK, Martin; TAMEZ, JR., Victoriano; YU, Bing; (237 pag.)WO2016/203405; (2016); A1;,
Piperidine – Wikipedia
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