With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.85908-96-9,N-Boc-2-Piperidone,as a common compound, the synthetic route is as follows.
85908-96-9, Phenylmagnesium bromide 1M in THF solution (28.9 mL, 28.9 mmol) (Aldrich) was added to a solution of tert-butyl 2-oxopiperidine-1-carboxylate (5.0 g, 25.1 mmol) (Aldrich) in THF (100 mL) at -78 C. Mixture was stirred at -78 C. for 40 minutes, and then poured into brine. The aqueous phase was extraced with ethyl acetate (2×) and the combined organic phase was dried (magnesium sulfate), filtered, and concentrated. The residue was purified by flash chromatography eluting with 5-40% ethyl acetate in hexanes to give tert-butyl 5-oxo-5-phenylpentylcarbamate. (Yield 4.97 g, 71.4%).
The synthetic route of 85908-96-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Anderson, Kevin; Chen, Yi; Chen, Zhi; Luk, Kin-Chun; Rossman, Pamela Loreen; Sun, Hongmao; Wovkulich, Peter Michael; US2012/184542; (2012); A1;,
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