71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
71985-80-3, 0-(1 H-BENZOTRIAZOL-1-YL)-N, N, N’, N’-tetramethyluronium hexafluorophosphate (395 mg, 1.04 MMOL) was added to a solution of 1-methylpiperidine-4-carboxylic acid hydrochloride (210 mg, 1.04 MMOL) in dichloromethane (10 ml) and the solution stirred for 30 minutes. The amine from example 4 (200 mg, 0.52 MMOL) was added and the reaction mixture was stirred at room temperature for 18 hours. The mixture was washed with aqueous sodium carbonate solution and the organic solution was dried over magnesium sulphate. The solution was evaporated under reduced pressure and the crude product was purified by column chromatography on silica gel using ethyl acetate: methanol : 0. 88 ammonia (90: 10: 1) as eluant, to afford the title compound as a white solid (195 mg). APCI MS M/Z 506 [MH] +
As the paragraph descriping shows that 71985-80-3 is playing an increasingly important role.
Reference：
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/74291; (2004); A1;,
Piperidine – Wikipedia
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