19099-93-5, 1-Cbz-Piperidin-4-one is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
n-Butyllithium is added dropwise to a solution at -20 C. of N,N,N’,N’-tetramethylethylenediamine in tetrahydrofuran. After stirring for thirty minutes, the mixture is cooled to -78 C. and a solution of (6-chloro-pyridin-2-yl)-tert-butyl carbamate in tetrahydrofuran is added. The reaction is maintained at -50 C. for two hours and then a solution of 4-oxo-piperidine-1-benzyl carboxylate in tetrahydrofuran is added dropwise. The reaction mixture is brought back to room temperature slowly and then heated at 40 C. for 18 hours. The reaction mixture is hydrolysed with a saturated aqueous solution of sodium hydrogen carbonate and then diluted with dichloromethane. The product is extracted with dichloromethane, the organic phases are combined, washed once with water and then dried over magnesium sulphate, filtered and concentrated under vacuum. The crude product is chromatographed on silica gel eluted with a heptane/ethyl acetate mixture, 70/30 and then 50/50. 7′-chloro-2′-oxo-1′,2′-dihydro-1H-spiro[piperidine-4,4′-pyrido[2,3-d][1,3]oxazine]-1-benzyl carboxylate is obtained in the form of a yellow solid.
19099-93-5, As the paragraph descriping shows that 19099-93-5 is playing an increasingly important role.
Reference：
Patent; GALDERMA RESEARCH & DEVELOPMENT; Fournier, Jean-Francois; Clary, Laurence; Thoreau, Etienne; (164 pag.)US2018/50992; (2018); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem