50541-93-0, Name is 4-Amino-1-benzylpiperidine, belongs to piperidines compound, is a common compound. 50541-93-0. In an article, authors is Akrami, Hamidreza, once mentioned the new application about 50541-93-0.
Cytotoxic activity and DNA binding property of new aminopyrimidine derivatives
Background: Chromene and anilinopyrimidine heterocyclics are attractive anticancer compounds that have inspired many researchers to design novel derivatives bearing improved an-ticancer activity. Method: A series of pyrimidine-fused benzo[f]chromene derivatives 6a-x were synthesized as an-ticancer hybrids of 1H-benzo[f]chromenes and anilinopyrimidines. The inhibitory activity of the synthesized compounds 6a-x against cell viability of human chronic myelogenous leukemia (K562), human acute lymphoblastic leukemia (MOLT-4) and human breast adenocarcinoma (MCF-7) cell lines was evaluated using MTT assay. The interaction of the most promising compound with calf-thymus DNA was also studied using spectrometric titrations and Circular Dichro-ism (CD) spectroscopy. Results: Most compounds showed promising activity against tested cell lines. Among them, 2,4-dimethoxyanilino derivative 6g exhibited the best profile of activity against tested cell lines (IC50s = 1.6-6.1 muM) with no toxicity against NIH3T3 normal cell (IC50 >200 muM). The spectro-metric studies exhibited that compound 6g binds to DNA strongly and may change DNA conformation significantly, presumably via a groove binding mechanism. Conclusion: The results of this study suggest that the prototype compound 6g can be considered as a novel lead compound for the design and discovery of novel anticancer agents.
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Reference£º
Piperidine – Wikipedia,
Piperidine | C5H12559N – PubChem