With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1172500-91-2,4-Benzenesulfonylpiperidine Hydrochloride,as a common compound, the synthetic route is as follows.
A solution of JV-(7-chloro-2-methylpyrazolo[l ,5-alpha]pyrimidin-5-yl)-4-(2- hydroxypropan-2-yl)benzamide (2F, 86 mg, 0.25 mmol), 4-(phenylsulfonyl)piperidine hydrochloride (145 mg, 0.50 mmol), and JV,jV-diisopropylethylamine (116 mg, 0.90 mmol) in DMF (1.0 mL) was stirred at 100 0C for 2h. After cooling to room temperature, the mixture was diluted with a few drops of DMSO and methanol, and was then purified by preparatory HPLC (40-55% MeCN/H2O gradient + 0.01% TFA). Lyophilization of the combined fractions gave the titled compound as a white solid (97.2 mg, 73%). 1H NMR (DMSO-d6) delta: 10.90 (s, IH), 7.99 (d, J = 8.8 Hz, 2H), 7.89 – 7.95 (m, 2H), 7.78 – 7.85 (m, IH), 7.68 – 7.76 (m, 2H), 7.60 (d, 2H), 7.28 (s, IH), 6.18 (s, IH), 4.53 (d, J = 12.6 Hz, 2H), 3.69 (tt, J = 11.8, 3.7 Hz, IH), 3.00 – 3.11 (m, 2H), 2.37 (s, 3H), 2.04 (d, J = 10.9 Hz, 2H), 1.75 (qd, J = 12.3, 3.8 Hz, 2H), 1.45 (s, 6H); ESI-MS: m/z 534.2 (M+H)+., 1172500-91-2
As the paragraph descriping shows that 1172500-91-2 is playing an increasingly important role.
Reference：
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; WO2009/123986; (2009); A1;,
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