71985-80-3, 1-Methylpiperidine-4-carboxylic acid hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
71985-80-3, EXAMPLE 234; J/V-r4-(6.6-Dimethyl-4-oxo-4.5.6.7-tetrahvdrori,31thiazolor5.4-clpyridin-2-ylV3.4- dihydro-2H- 1 ,4-benzoxazin-7-yl]- 1 -methylpiperidine-4-carboxamide; To a stirred solution of Example 233 (0.049 g, 0.15 mmol), 2-(lH-benzotriazol-l- yl)-l,l,3,3-tetramethyluronium hexafluorophosphate (0.111 g, 0.29 mmol) and 1 -methyl – piperidine-4-carboxylic acid hydrochloride (0.034 g, 0.19 mmol) in DMF (0.5 mL) was added DIPEA (0.06 mL, 0.35 mmol). The reaction mixture was stirred at r.t. for 16 h. MeCN (1 mL) and water (1 mL) were added. The insoluble material was filtered, and the filtrate concentrated in vacuo. Purification by preparative etaPLC (Method 6) gave the title compound (0.035 g, 51%) as a yellow solid. deltaeta (CD3OD) 7.91 (IH, d, J9.0 Hz), 7.37 (IH, d, J 2.3 Hz), 7.11 (IH, dd, J 8.9 and 2.3 Hz), 4.40-4.30 (2H, m), 4.20-4.09 (2H, m), 3.62 (2H, d, J 12.6 Hz), 3.17-3.02 (2H, m), 2.92 (3H, s), 2.89 (2H, s), 2.76-2.60 (IH, m), 2.34-1.91 (4H, m), 1.39 (6H, s). Exchangeable protons were not observed. LCMS (ES+) 456.21 (M+H)+, RT 1.80 minutes (Method I).
The synthetic route of 71985-80-3 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; UCB PHARMA S.A.; WO2008/1076; (2008); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem