With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5773-58-0,3-Methylpiperidin-4-one,as a common compound, the synthetic route is as follows.
1-(3-Chloropyridin-2-yl)-3-methylpiperidin-4-one was prepared by dissolving 19.2 g 3-methylpiperidin-4-one (168.9 mmol) and 25 g of Compound of Formula A (168.9 mmol) in DMSO (400 mL) under a nitrogen atmosphere to form a reaction mixture. The reaction mixture was stirred at 85 C for 12 hours. Therefter, the solvent was removed under reduced pressure. The residue was purified by column chromatography on a silica gel column, using a gradient of from 10:90 to 98:2 (by volume) ethyl acetate:hexane as an eluent, to provide 9 g of l-(3-chloropyridin-2-yl)-3-methylpiperidin-4-one., 5773-58-0
The synthetic route of 5773-58-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; EURO-CELTIQUE, S.A.; WO2005/4866; (2005); A1;,
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