1187173-43-8, 2,7-Diazaspiro[4.5]decan-1-one hydrochloride is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 2,7-diazaspiro[4.5]decan-1 -one hydrochloride (0.572 g, 3mmol) and triethylamine (0.836 mL, 6.00 mmol) in dichloromethane (DCM) (15ml_), cooled in an ice-water bath, was added 4-bromo-2-(trifluoromethyl)benzenesulfonyl chloride (0.971 g, 3.00 mmol). The reaction was allowed to warm to room temperature and stirred for 18 hours.The reaction was diluted with DCM (35 ml), washed with water (30ml_), passed through a hydrophobic frit and reduced in vacuo. The residue was purified by silica chromatography (Biotage SP4) eluting with 60% EtOAc in iso-hexanes (3 column volumes), a gradient from 60-100% EtOAc (over 9 column volumes) then EtOAc (3 column volumes) to yield 7-{[4-bromo-2-(trifluoromethyl)phenyl]sulfonyl}-2,7- diazaspiro[4.5]decan-1 -one as a white solid (0.826g, 62%)1H NMR (400 MHz, Chloroform-d) d ppm 1.61 – 1 .67 (m, 1 H) 1.69 – 1 .84 (m, 3 H) 2.05 (s, 1 H) 2.43 (s, 1 H) 2.59 – 2.67 (m, 1 H) 2.85 (d, J=12.7 Hz, 1 H) 3.32 – 3.45(m, 2 H) 3.67 (d, J=12.5 Hz, 1 H) 3.80 – 3.87 (m, 1 H) 5.72 (br. s., 1 H) 7.80 – 7.88 (m, 2 H) 8.01 (d, J=1.5 Hz, 1 H)
1187173-43-8, As the paragraph descriping shows that 1187173-43-8 is playing an increasingly important role.
Reference：
Patent; CONVERGENCE PHARMACEUTICALS LIMITED; GLEAVE, Robert James; HACHISU, Shuji; PAGE, Lee William; BESWICK, Paul John; WO2011/141728; (2011); A1;,
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