321337-38-6, tert-Butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of tert-butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate (350 mg, 1.14 mmol) in DMF (5 mL) was added sodium hydride (0.14 g, 5.7 mmol) and iodomethane (0.81 g, 5.7 mmol). The reaction was stirred at ambient temperature for 1 h. Water (20 mL) was added to the reaction vessel and the resulting biphasic mixture was extracted with DCM (3 x 50 mL). The organic phase was washed with saturated aqueous NaCl (5 x 25 mL). The combined organics were dried over anhydrous Na2SO4, filtered and concentrated in vacuo. The resulting oil was purified by flash column chromatography with a gradient elution of hexanes (100%) to hexanes (90%) and EtOAc (10%) to provide tert-butyl 4-(4-(methoxymethyl)phenoxy)piperidine-1-carboxylate (350 mg, 1.09 mmol) as a colorless oil.
321337-38-6, 321337-38-6 tert-Butyl 4-(4-(hydroxymethyl)phenoxy)piperidine-1-carboxylate 22632413, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; SUNOVION PHARMACEUTICALS INC.; HEFFERNAN, Michele L.R.; HARDY, Larry Wendell; BROWN, Scott P.; HERMAN, Lee W.; (180 pag.)WO2018/26371; (2018); A1;,
Piperidine – Wikipedia
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