1211587-42-6, Benzyl 4-((chlorosulfonyl)methyl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
To a solution of 5-cyclopropyl-N-(2-methylpiperidin-4-yl)-1,2-oxazole-3- carboxamide hydrochloride (920 mg, 3.22 mmol) in DCM (40ml) was added DIPEA (3.37ml, 19.3 mmol) followed by benzyl 4-[(chlorosulfonyl)methyl]piperidine-1- carboxylate (1175 mg, 3.54 mmol) as a solution in DCM (10ml) and the reaction was left at rt overnight. The reaction was diluted with DCM (100ml) and washed with water (50ml) and brine (50ml). The combined aqueous layers were back-extracted with EtOAc (2x25ml). The combined organic layers were dried over Na2SO4, filtered and concentrated. The residue was purified by Isolera over SiO2 (100g), dry loaded and eluted with a gradient of EtOAc in heptane from 12 to 100% then with a gradient of MeOH in EtOAc from 0 to 20% to yield 0.92 g (47%) of sulfonamide as a white solid. TLC (2.5% MeOH in DCM), rf:0.30. 1H NMR (500 MHz, Chloroform-d) 7.40- 7.28 (m, 5H), 6.77 (d, J = 7.4 Hz, 1H), 6.32 (s, 1H), 5.12 (s, 2H), 4.20 (ddt, J = 16.0, 7.7, 4.5 Hz, 3H), 3.76- 3.63 (m, 2H), 3.21 (ddd, J = 13.5, 7.4, 3.8 Hz, 1H), 2.83 (hept, J = 6.4 Hz, 4H), 2.24- 1.90 (m, 6H), 1.79- 1.69 (m, 2H), 1.44 (d, J = 6.9 Hz, 3H), 1.33- 1.22 (m, 2H), 1.16- 1.09 (m, 2H), 1.01 – 0.96 (m, 2H). LCMS analysis (METCR1673 Generic 2 minutes), 100%, 1.38 min, [MH]+.=545.00.
1211587-42-6, The synthetic route of 1211587-42-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; EPIZYME, INC.; MITCHELL, Lorna Helen; BELL, Andrew Simon; CHESWORTH, Richard; FOLEY, Megan Alene Cloonan; KUNTZ, Kevin Wayne; MILLS, James Edward John; MUNCHHOF, Michael John; (375 pag.)WO2016/40515; (2016); A1;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem