With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.141774-61-0,tert-Butyl (piperidin-2-ylmethyl)carbamate,as a common compound, the synthetic route is as follows.
A solution of 4-nitrophenyl(4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)carbamate (2.08 g), tert-butyl (piperidin-2-ylmethyl)carbamate (1.19 g) and TEA (2.20 mL) in N,N-dimethylacetamide (25.0 mL) was stirred at room temperature for 2 hr. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (2.17 g). 1H NMR (300 MHz, CDCl3) delta 1.36-1.54 (11H, m), 1.63-1.83 (4H, m), 2.70 (1H, t, J = 12.5 Hz), 3.12-3.28 (1H, m), 3.29-3.43 (1H, m), 4.03-4.22 (1H, m), 4.35 (1H, d, J = 12.5 Hz), 5.01 (1H, brs), 7.77 (2H, d, J = 8.7 Hz), 7.95-8.07 (2H, m), 8.56 (1H, brs) .
141774-61-0, The synthetic route of 141774-61-0 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Takeda Pharmaceutical Company Limited; KAIEDA, Akira; ISHII, Naoki; NARA, Hiroshi; YOSHIKAWA, Masato; DAINI, Masaki; (63 pag.)EP3342772; (2018); A1;,
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