With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.683233-14-9,(R)-tert-Butyl 2-(aminomethyl)piperidine-1-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of (R)-tert-butyl 2-(aminomethyl)piperidine- 1 -carboxylate(475 mg, 2.216 mmol) in DCM (5.0 mL) at 0 C was added iPr2Net (0.424 mL,2.43 8 mmol) followed by benzyl chloroformate (0.693 mL, 2.43 8 mmol). The resulting mixture was then stirred at 0 C for 2 h and at room temperature for 14 h. Then, saturated NaHCO3 (30 mL) was added to the mixture and the mixture was stirred at room temperature for 3 mm. The organic layer was collected andaqueous layer was extracted with EtOAc (1 x 20 mL). The combined organic extracts were dried over Na2504 and concentrated in vacuo. Chromatographic purification of the residue (silica gel, 0% to 100% EtOAc/heptane) provided (R)tert-butyl 2-((((benzyloxy)carbonyl)amino)methyl)piperidine- 1 -carboxylate (772 mg, 2.216 mmol, 100% yield) as an oil. MS (ESI, +ve ion) m/z 371.1 (M+Na)., 683233-14-9
The synthetic route of 683233-14-9 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; AMGEN INC.; HARRINGTON, Paul E.; ASHTON, Kate; BROWN, Sean P.; KALLER, Matthew R.; KOHN, Todd J.; LANMAN, Brian Alan; LI, Kexue; LI, Yunxiao; LOW, Jonathan D.; MINATTI, Ana Elena; PICKRELL, Alexander J.; STEC, Markian M.; TAYGERLY, Joshua; (991 pag.)WO2018/183418; (2018); A1;,
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