With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3970-68-1,4-Methylpiperidin-4-ol,as a common compound, the synthetic route is as follows.,3970-68-1
A mixture of 11 (100 mg, 0.35 mmol), 4-methylpiperidin-4-ol (202 mg, 1.7mmol), and potassium carbonate (484 mg, 3.5 mmol) in anhydrous DMSO (3 mL) was stirred at 90 C overnight. The reaction mixture was diluted with water (20 mL) and extracted with ethyl acetate (3 ¡Á 50 mL). Combined organic layers were dried over anhydrous Na2SO4 and concentrated in vacuo. The crude material was purified by flash chromatography using MeOH/DCM (1/100, v/v) to afford 13a as a yellow solid (80 mg, 60%).
3970-68-1 4-Methylpiperidin-4-ol 15649174, apiperidines compound, is more and more widely used in various fields.
Reference£º
Article; Yang, Hao; Murigi, Francis N.; Wang, Zhijian; Li, Junfeng; Jin, Hongjun; Tu, Zhude; Bioorganic and Medicinal Chemistry Letters; vol. 25; 4; (2015); p. 919 – 924;,
Piperidine – Wikipedia
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