With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.177948-02-6,tert-Butyl N-[(4-hydroxypiperidin-4-yl)methyl]carbamate,as a common compound, the synthetic route is as follows.
(1) 6-Bromo-1-phenyl-1-hexanone (2.9 g) and potassium carbonate (3 g) were added to a solution of 4-hydroxy-4-tert-butoxycarbonylaminomethylpiperidine (2.5 g) in dimethylformamide (40 ml), and the mixture was stirred at 60C for 2 hr. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The organic layer was washed with saturated brine, dried and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (chloroform:methanol=10:1) to give 3.74 g of 4-hydroxy-1-(6-oxo-6-phenylhexyl)-4-tert-butoxycarbonylaminomethylpiperidine. 1H-NMR (CDCl3,ppm)delta:1.36-1.82(20H,m), 2.36-2.88(4H,m), 2.60-2.67(2H,m), 2.97(2H,t,J=7.3Hz), 3.14(2H,d,J=6.6Hz), 5.01(1H,br), 7.42-7.59(3H,m), 7.93-7.97(2H,m)
177948-02-6, The synthetic route of 177948-02-6 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD.; EP873990; (1998); A1;,
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