1169563-99-8, tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate is a piperidines compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 18 – Preparation of Compound 15 The synthesis of Compound 15 followed the procedure of General Procedure 4 following: Compound 14 Compound 15 To a solution of tert-butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate (Compound 14, 3.0 g, 11.3 mmol, 1.0 eq) in methanol (30 mL) was added acetic acid (0.67 mL, 11.3 mmol, 1.0 eq), followed by 5-chlorothiophene-2-carbaldehyde (1.81 g, 12.4 mmol, 1.1 eq) portionwise. The reaction was stirred for 2 hours at room temperature. To the reaction mixture was then added sodium cyanoborohydride (1.42 g, 22.6 mmol, 1.5 eq) portionwise over a period of 45 minutes. The reaction mixture was stirred for a further 3 hours. After reaction completion, the reaction mixture was concentrated under reduced pressure, and the residue was poured into stirred ice cold water and extracted with ethyl acetate. The organic layer was dried over sodium sulfate, filtered and evaporated under reduced pressure. The residue was purified by column chromatography using neutral silica gel, eluting with 5-10% methanol in dichloromethane, yielding tert-butyl 4-(5-(((5-chlorothiophen-2-yl)methyl)amino)- 1H-pyrazol-3-yl)piperidine-1-carboxylate (Compound 15, 3.0 g, yield: 68%) m/z[M+H]+ 396.14 1H NMR (DMSO-d6, 400 MHz) delta 11.34 (1H, s), 6.87-6.94 (1H, q), 6.834-6.843 (1H, q), 5.68 (1H, s), 4.275-4.288 (1H, s), 3.945-3.975 (2H, d),2.786- 2.796 (2H, d), 2.623-2.681(1H, d), 1.725-1.995 (2H, d), 1.402-1.559 (12H, m) ppm.
1169563-99-8, 1169563-99-8 tert-Butyl 4-(5-amino-1H-pyrazol-3-yl)piperidine-1-carboxylate 49761279, apiperidines compound, is more and more widely used in various fields.
Reference：
Patent; VERSEON CORPORATION; SHORT, Kevin Michael; ESTIARTE-MARTINEZ, Maria de los Angeles; KITA, David Ben; SHIAU, Timothy Philip; (340 pag.)WO2016/138532; (2016); A1;,
Piperidine – Wikipedia
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