With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.10338-57-5,4-(Piperidin-1-yl)benzaldehyde,as a common compound, the synthetic route is as follows.,10338-57-5
General procedure: The pyrone (30mmol) and morpholino (35mmol) are placed in a round bottom flask. Cyclohexane (45ml) was used as a solvent and p-toluenesulfonic acid as a catalyst, and the reaction conditions is refluxed in an oil bath at 90C condition 6h. Subsequently, at the rear end of the one-step reaction, cyclohexane was removed by rotary evaporation, and added difluorobenzaldehyde (30mmol) with ethanol as a solvent, then underwent an oil bath at 78C reflux condition monitored by thin-layer chromatography (TLC). Completion of the reaction is the end point of symmetry product just appeared. The reaction solution was cooled at room temperature, using 15% hydrochloric acid solution to adjust PH to acid field. Ethanol was removed by rotary evaporator and then extracted with ethyl acetate, purified by column chromatography. Unilateral product obtained reacted with different aldehydes dissolved in ethanol, 10% NaOH solution as catalyst to perform final products.
10338-57-5 4-(Piperidin-1-yl)benzaldehyde 291354, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Wu, Jianzhang; Wu, Shoubiao; Shi, Lingyi; Zhang, Shanshan; Ren, Jiye; Yao, Song; Yun, Di; Huang, Lili; Wang, Jiabing; Li, Wulan; Wu, Xiaoping; Qiu, Peihong; Liang, Guang; European Journal of Medicinal Chemistry; vol. 125; (2017); p. 1321 – 1331;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem