664362-16-7,With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.664362-16-7,1-Boc-3-Ethynylpiperidine,as a common compound, the synthetic route is as follows.
Hydrochloric acid (gas) (excess) wasbubbled through a mixture of tert-butyl 3-ethynylpiperidine-1-carboxylate (90mg, 0.43 mmol) in dichloromethane (5 mL) at 0oC for 15 minutes. Thesolvent was evaporated under reduced pressure to give the 3-ethynylpiperidinehydrochloride (50 mg, yield: 80%) as white solid which was used directlywithout further purification. MS (M+H)+ = 110.3
664362-16-7 1-Boc-3-Ethynylpiperidine 21963855, apiperidines compound, is more and more widely used in various fields.
Reference：
Article; Schwaid, Adam G.; Ruangsiriluk, Wanida; Reyes, Allan R.; Cabral, Shawn; Rajamohan, Francis; Tu, Meihua; Ward, Jessica; Carpino, Philip A.; Bioorganic and Medicinal Chemistry Letters; vol. 26; 8; (2016); p. 1993 – 1996;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem