With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.220394-97-8,1-Boc-4-(Cbz-amino)piperidine,as a common compound, the synthetic route is as follows.
Benzyloxycarboxamide-tert-butyl piperidine-1-carboxylate (0.334 g, 1 mmol),Was dissolved in 5 mL of chloroform, TFA (3.42 g, 30 mmol) was dropped at room temperature,The reaction was stirred for 1h, the excess TFA was distilled off under reduced pressure,Add DIEA (0.258g, 2mmol), cyclopentanone 1mL, sodium triacetoxyborohydride (0.636g, 3mmol), the reaction at room temperature for 1h, add a small amount of water quenched reaction, saturated sodium bicarbonate to adjust pH = 6 ~ 7, The mixture was extracted with dichloromethane and dried over anhydrous sodium sulfate. After concentration, the residue was subjected to column chromatography to obtain 0.314 g of a white solid in a yield of 104%., 220394-97-8
The synthetic route of 220394-97-8 has been constantly updated, and we look forward to future research findings.
Reference：
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Chen Xiaoguang; Jin Jing; Zhu Lina; Zhang Chongjing; (85 pag.)CN102250075; (2016); B;,
Piperidine – Wikipedia
Piperidine | C5H11N – PubChem